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litaba

Sekhetho

Melanoma e etsa karolo ea 4 lekholong feela ea mofetše oa letlalo empa ke e 'ngoe ea lihlahala tse kotsi haholo. Dacarbazine ke setlhare se ikhethileng bakeng sa kalafo ea melanoma naheng ea Brazil ka sistimi ea bophelo bo botle ea sechaba haholoholo ka theko ea eona e tlase. Leha ho le joalo, ke moemeli oa alkylating oa maemo a tlase mme o fana ka karabelo ea kalafo ka linyeoe tse 20% feela. Lithethefatsi tse ling tse fumanehang kalafong ea melanoma li theko e boima, 'me lisele tsa hlahala hangata li ba le ho hanela meriana ena. Ntoa khahlanong le melanoma e hloka hore ho be le li-novel, meriana e ikhethang e sebetsang ho bolaeeng lisele tsa hlahala tse sa thibeleng lithethefatsi. Dibenzoylmethane (1,3-diphenylpropane-1,3-dione) lihlahisoa tse ts'episang li-antitumor agents. Thutong ena, re batlisitse phello ea cytotoxic ea 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) ho lisele tsa B16F10 tsa melanoma hammoho le ho sebelisana ha eona ka kotloloho le molek'hule ea DNA e sebelisang li-tweezers tsa optical. DPBP e bonts'a sephetho se ts'episang khahlano le lisele tsa hlahala mme e na le index ea khetho ea 41.94. Hape, re bontšitse bokhoni ba DPBP ho sebelisana ka kotloloho le molek'hule ea DNA. Taba ea hore DPBP e ka sebelisana le DNA in vitro e re lumella ho nahana hore tšebelisano e joalo e kanna ea etsahala le vivo, ka hona, DPBP e kanna ea ba mokhoa o mong oa ho phekola bakuli ba melanoma e hananang le lithethefatsi. Liphuputso tsena li ka tataisa nts'etsopele ea litlhare tse ncha hape tse sebetsang hantle.

Litšoantšo tse hlakileng

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Morero oa palo ea lefu la sele e fumanoeng bakeng sa kompone ea DPBP khahlano le meloko ea melan-A le B16F10 maemong a fapaneng. Li-indices tsa khetho (SI = IC50 melan-A / IC50 B16F10) e ne e le 41.94.                    

E phatlalalitsoe ke Elsevier BV

Sekhetho

Dibenzoylmethane (DBM) ke karolo e nyane ea licorice le analogic ea β-diketone ea curcumin. Ho fepa 1% DBM lijong ho litoeba tsa Sencar nakong ea qalo le linako tsa kamora ho qala li thibetse ka matla 7,12-dimethylbenz [a] anthracene (DMBA) e bakileng ho eketseha ha hlahala ea mammary le ketsahalo ea hlahala ea mammary ka 97%. Ho ea pele lipatlisisong tsa vivo ho hlakisa mekhoa e ka bang teng ea tšebetso ea thibelo ea DBM, ho fepa 1% DBM lijong tsa AIN-76A ho holisa litoeba tsa Sencar bakeng sa libeke tse 4-5 ho theotse boima ba metsi a pōpelo ka 43%, e thibetse sekhahla sa keketseho ea lisele tsa epithelial ea mammary ka 53%, epithelium ea popelo ka 23%, le stroma ea uterine ka 77%, ha litoeba li bolaoa nakong ea karolo ea pele ea estrus ea potoloho ea estrous. Ho feta moo, ho fepa 1% DBM lijong ho litoeba tsa Sencar libekeng tse 2 pele ho moo, nakong ea beke le 1 kamora kalafo ea DMBA (intubation ea 1 mg DMBA ka toeba hanngoe ka beke bakeng sa libeke tse 5) e sitisitse ho theoa ha kakaretso ea DMBA-DNA e tlatsetsang ho mammary litšoelesa ka 72% ba sebelisa tlhahlobo ea "post-32P". Kahoo, ho fepa 1% ea phepelo ea DBM ho litoeba tsa Sencar ho thibela sebopeho sa li-adducts tsa DMBA-DNA litšoeleseng tsa mammary le ho theola sekhahla sa keketseho ea tšoelesa ea mammary ka vivo. Liphetho tsena li ka hlalosa liketso tse matla tsa thibelo ea phepo ea DBM ho mammary carcinogenesis ho litoeba.


Nako ea poso: Aug-12-2020